Close

Please fill all fields and submit the form.

Name:
Email:

Phone:

Notes:



Close

Please fill out all fields in the form. Please be as detailed as possible. We will respond with pricing and availability within 1-2 business days.

Name:
Company/Institution:

Phone:
Email:

Disease:

Organ/Tissue type:

Format:

Number of patients/donors required for the study:

Clinical Specifications:

Applications/Research topic:

JAK2 Mutation Detection Kit

JAK2 Mutation Detection Kit Description

The JAK family of non-receptor tyrosine kinases, includes JAK1, JAK2, JAK3, and TYK2. Growth factors and cytokines can regulate gene transcription through JAK-dependent activation of signal transducer and activator of transcription (STAT). The JAK-STAT signal transduction pathway regulates cell proliferation, differentiation, apoptosis and immune regulation. Activation of JAK2 by mutation of the amino acid at position 617 (V617F ) is associated with myeloproliferative disorders, including polycythemia vera (mutations found in 90% of cases), essential thrombocythemia (50%) and idiopathic myelofibrosis (50%). JAK2 mutation is the main diagnostic indicator of MPD. The ADx JAK2 V617F Mutation Detection Kit is a highly selective and sensitive assay for detecting the V617F mutation in the JAK2 oncogene. This technology allows detection of 1% mutant DNA in a background of 99% normal DNA, while ensuring that false negatives are minimized. The procedure is easily adapted for use in high-throughput sample processing.