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SV40 Viral Vectors for Cell Immortalization

SV40 T antigen has been shown to be the most simple and reliable agent for the transfromation of many different cell types in culture. The mechanism of SV40 T antigen in cell immortalization is well studied. For the most part, viral genes achieve immortalization by inactivating the tumor suppressor genes (p53, Rb and others) that can induce a replicative senescent state in cells. Recent studies have also shown that SV40 T antigen can induce Telomerase activity in the infected cells.
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Lenti-SV40 Tta Virus
Lentivirus vector with both large and small SV40 T antigens 		CIP-0014 10ml Request Quote